Other doctors have demonstrated that 5 mg/day of atorvastatin (Lipitor) yielded fully 65% of the effect of 80 mg/day as measured by diminished cardiovascular risk. Take once daily. Lipitor is effective at lowering cholesterol; however, its use may be limited by side effects such as muscle pain. The data show that rosuvastatin 5 mg is highly effective in lowering LDL-C to recommended levels for most patients (mean reductions ranging from 42 to 52%). Others have confirmed this effect using other statins. Tips. Lipitor also increases HDL cholesterol. 1 Maximum-dose Lipitor® reduced levels of harmful low density lipoprotein (LDL) to an average of 77 mg/dL. The implications of this are profound. In the 2005 TNT study, 10,001 people with stable heart disease received either maximum-dose 80-mg Lipitor® or a standard dose of 10-mg Lipitor® daily. That and my cholesterol numbers are phenomenal. Generic atorvastatin is available. Just one-sixteenth of the original dose capable of giving two-thirds of the effect. Sub 100 total. Possibly more effective than other statins. How Effective Is Maximum-Dose Lipitor®? It is effective at reducing total cholesterol, LDL cholesterol, and triglycerides. The TNT Heart Study. It took four years, though. My Lipitor, atorvastatin, dose just got cut in half. Alternate-day treatment with [Lipitor] atorvastatin is comparable in efficacy and safety to the established daily treatment regimen, thus being a cost effective alternative." May be taken at any time of the day (morning or night); however, it is best to be consistent with the time you take Lipitor. It is available in 10 mg, 20 mg, 40 mg, and 80 mg tablets that are typically taken once daily. It was totally, and remains, a nonissue in my case. Another study reported similar results, that every other day dosing of long acting statins, like Lipitor, lowered cholesterol levels just as effectively as taking the drugs every day. 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